Ipamorelin
The first highly selective growth hormone secretagogue that stimulates GH release without affecting cortisol, prolactin, or other pituitary hormones.
Ipamorelin is a pentapeptide growth hormone secretagogue that selectively stimulates pulsatile GH release from the pituitary gland via the ghrelin receptor (GHS-R1a). Unlike earlier GH secretagogues such as GHRP-6, ipamorelin does not elevate cortisol, ACTH, or prolactin, making it one of the cleanest GH-stimulating peptides available. It produces both immediate and sustained GH pulses that promote recovery, lean mass, and metabolic health.
⚙️ Mechanism of Action
Ipamorelin binds to the ghrelin/GHS receptor on pituitary somatotrophs, triggering calcium influx and GH vesicle release in a pulsatile, physiological manner. It amplifies natural GH secretion patterns without desensitizing the receptor or suppressing endogenous GH production. Its high selectivity means it does not activate ACTH or prolactin pathways, distinguishing it from less selective secretagogues.
✅ Benefits
- •Selective GH release without cortisol or prolactin elevation
- •Supports lean muscle growth and recovery
- •Promotes improved sleep quality
- •Enhances fat metabolism
- •Supports bone density and joint health
⚠️ Risks & Considerations
- •Headache
- •Water retention
- •Transient numbness or tingling
- •Potential insulin sensitivity changes with prolonged use
- •Fatigue
📚 References
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