Glutathione
The body's most abundant endogenous antioxidant, critical for detoxification, immune function, and protection against oxidative stress.
Glutathione (GSH) is a tripeptide composed of glutamine, cysteine, and glycine that serves as the master antioxidant in every cell of the body. It plays essential roles in detoxification, immune regulation, and the recycling of other antioxidants like vitamins C and E. Levels naturally decline with age, and supplementation has been shown to elevate whole blood GSH by up to 40% and boost natural killer cell activity by up to 400%.
⚙️ Mechanism of Action
Glutathione neutralizes reactive oxygen species and free radicals through its thiol group, cycling between reduced (GSH) and oxidized (GSSG) forms. It conjugates with toxins via glutathione S-transferase enzymes, facilitating their excretion through bile and urine. GSH also regenerates other antioxidants, maintains protein thiol status, and supports T-cell proliferation and NK cell cytotoxicity for immune defense.
✅ Benefits
- •Powerful detoxification of heavy metals and environmental toxins
- •Boosts NK cell activity by up to 400%
- •Supports recycling of vitamins C and E
- •Protects mitochondria from oxidative damage
- •May improve skin brightness and reduce hyperpigmentation
- •Supports liver function and phase II detoxification
⚠️ Risks & Considerations
- •Bloating and cramping with oral forms
- •Rare allergic reactions with IV administration
- •Zinc depletion with long-term high-dose use
- •May interfere with certain chemotherapy agents
📚 References
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