Peptides/LL-37
LL-37
Immuneemerging evidence

LL-37

Antimicrobial peptide for immune defense

LL-37 is the only human cathelicidin-derived antimicrobial peptide. It plays a critical role in innate immunity, defending against bacteria, viruses, and fungi while also modulating inflammatory responses and wound healing.

⚙️ Mechanism of Action

LL-37 disrupts microbial membranes directly and recruits immune cells to infection sites. It also promotes angiogenesis, wound closure, and can modulate adaptive immune responses through dendritic cell activation.

Benefits

  • Broad-spectrum antimicrobial activity
  • Biofilm disruption (Lyme, MRSA)
  • Wound healing acceleration
  • Immune system modulation
  • Anti-inflammatory in chronic conditions

⚠️ Risks & Considerations

  • Limited clinical trial data for therapeutic use
  • Potential cytotoxicity at high concentrations
  • May exacerbate certain autoimmune conditions
  • Sourcing and purity concerns
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