Semax
A synthetic ACTH(4-10) analog with pronounced nootropic and neuroprotective properties, approved in Russia for stroke and cognitive disorders.
Semax is a heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from ACTH that retains neurotrophic activity while lacking hormonal effects on the adrenal cortex. Developed at the Russian Academy of Sciences, it is approved in Russia for treatment of stroke, cognitive disorders, and optic nerve atrophy. Clinical studies demonstrate improvements in attention, short-term memory, and BDNF levels, with onset of action within 15-20 minutes via intranasal administration.
⚙️ Mechanism of Action
Semax upregulates brain-derived neurotrophic factor (BDNF) and its receptor trkB in the hippocampus, enhancing synaptic plasticity and neuronal survival. It modulates the expression of genes related to immune and vascular systems in ischemic brain tissue, reducing inflammation while promoting angiogenesis. The Pro-Gly-Pro C-terminal modification extends its biological activity to 20-24 hours despite rapid peptide clearance, likely through sustained downstream gene expression changes.
✅ Benefits
- •Rapid cognitive enhancement within 15-20 minutes
- •Increases BDNF levels in the hippocampus
- •Neuroprotective effects in stroke recovery
- •Improves attention and short-term memory
- •No hormonal side effects despite ACTH origin
- •Well-tolerated intranasal delivery
⚠️ Risks & Considerations
- •Nasal irritation with intranasal use
- •Mild headache
- •Dizziness (uncommon)
- •Hair loss reported rarely at high doses
📚 References
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