5-Amino-1MQ
A small molecule inhibitor of NNMT that boosts NAD+ levels and promotes fat metabolism without affecting appetite.
5-Amino-1MQ is a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that depletes NAD+ in fat cells. By blocking NNMT, it preserves intracellular NAD+ levels, suppresses lipogenesis, and shrinks adipocytes. In preclinical models, treated mice showed 30-40% reductions in fat cell size without changes in food intake.
⚙️ Mechanism of Action
5-Amino-1MQ inhibits NNMT, preventing the methylation and degradation of NAD+ in adipose tissue. This preserves NAD+ availability for metabolic processes, increases cellular energy expenditure, and suppresses fat storage pathways. The result is enhanced lipolysis and reduced adipocyte size without hormonal or appetite-related side effects.
✅ Benefits
- •Reduces fat cell size by up to 30-40% in preclinical models
- •Boosts intracellular NAD+ levels
- •Does not affect appetite or food intake
- •Supports cellular energy metabolism
- •May improve age-related metabolic decline
⚠️ Risks & Considerations
- •Limited human safety data available
- •Potential gastrointestinal discomfort
- •Headache reported anecdotally
- •Not yet evaluated in clinical trials
📚 References
Latest Videos
0:50Doctor Reveals Peptide that Shrinks Fat Cells & Boosts Insulin Sensitivity: 5-amino-1-MQ!
This Is Not Covered - Dr. Ashley Froese
8:54Is 5-Amino-1MQ A Peptide
Regan Archibald
51:32Retatrutide and 5-Amino-1-MQ Combined - a respected functional medicine practitioner
a respected functional medicine practitioner
15:09What Is 5-Amino-1MQ? How It Works (And Why Most Dosing Is Wrong)
Josh Holyfield
9:40What Does 5-Amino-1MQ Do
Regan Archibald
Quick Facts
Related Peptides
