SLU-PP-332
A synthetic ERR pan-agonist that mimics aerobic exercise at the molecular level, increasing fat oxidation and endurance without physical activity.
SLU-PP-332 is a small molecule agonist of estrogen-related receptors (ERRalpha, beta, and gamma) developed at Washington University in St. Louis that activates an aerobic exercise genetic program. In mouse models, it increased energy expenditure, fat oxidation, and exercise endurance while reducing fat mass accumulation. It represents a novel class of exercise mimetics with potential applications for metabolic disease and conditions limiting physical activity.
⚙️ Mechanism of Action
SLU-PP-332 activates ERRalpha with highest potency, inducing expression of DDIT4, a key protein normally triggered by short bouts of aerobic exercise. This activation upregulates PGC-1alpha, driving mitochondrial biogenesis and fatty acid oxidation pathways. The compound increases fast oxidative (Type IIa) skeletal muscle fibers and enhances mitochondrial function and cellular respiration, effectively replicating the molecular signature of physical exercise.
✅ Benefits
- •Mimics molecular benefits of aerobic exercise
- •Increases energy expenditure and fat oxidation
- •Enhances exercise endurance in animal models
- •Reduces fat mass accumulation
- •Promotes Type IIa oxidative muscle fiber development
- •Potential for patients unable to exercise
⚠️ Risks & Considerations
- •No human safety data available
- •Preclinical only - side effect profile unknown
- •Potential hormonal interactions (ERR-related)
- •Long-term effects on muscle and metabolism unstudied
📚 References
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